Thursday, December 19, 2019

Dementi A Clinical State Caused By Neurodegeneration Essay

Dementia is a clinical state caused by neurodegeneration and characterized by a loss of function in cognitive domains and behavior. There are several different causes of dementia including Alzheimer’s disease (AD), vascular dementia, dementia with Lewy bodies, and frontotemporal dementia (FTD). Hippocampal sclerosis of aging (HS-aging) is prevalent in people of advance age, manifests with distinct neuropathological properties, and can be present with or without other dementia causes and vascular diseases [1]. Although HS-aging is poorly understood, this phenomena may describe a proportion of non-AD dementia [2]. The prevalence of HS-aging pathology ranges from 5 to 30% in older people [3-6]. HS-aging is generally diagnosed postmortem by the presence of TAR DNA binding protein 43 (TDP-43). The clinical signs and symptoms of HS-aging are similar to those of AD with amnestic memory deficits [7, 8]. Because of the overlapping symptomology, HS-aging is often clinically misdiagnosed as AD [7-9]. AD is characterized by accumulation of amyloid plaques and neurofibrillary tangles [10], while HS-aging is pathologically characterized by neuronal loss with gliosis in the subiculum and Cornu Ammonis area 1 (CA1) region of the hippocampus, which can occur unilaterally or bilaterally [6, 7]. Genetic risk factors for HS-aging have been recently identified. Unlike AD, the apolipoprotein E4 (APOE4) genotype is not a risk factor for HS-aging [11]. Potassium channel subfamily M regulatory

Wednesday, December 11, 2019

Internet Piracy free essay sample

Internet Piracy has become a worldwide phenomenon. In the U. S. Alone more than 100 songs are downloaded every minute. With this growing problem, 3 main groups suffer. The recording artist suffers financially, the ARIA (The Recording Association of America) also suffers financially and finally the downloaded suffers if caught. This catch 22 tool has been a thorn In the side of technology since Its Introduction In 1999. Since then, downloading- or peer-2-peer sharing- has become one of the worst acts of technology affecting the world at large.Since the introduction of Anapest back in the year 2000, many more PEP sharing outworks have been invented to keep the illegal industry alive that left the ARIA in a fix. However, in the light of such programs there has also been uproar of other legal PEP programs that offer the same speed for a price. Many people dont believe in paying a price to get their music. We will write a custom essay sample on Internet Piracy or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The ARIA, which collectively represents every major and minor artist out in the market right now has been slapped with programs taking profits from the artist as well as the industry It self.In an effort to control pirating, the ARIA, according to an article in Information Week, the ARIA has been trying to reassure people to stop downloading by sending out more than . .. 400 letters to 13 U. S. Unlettered advising of potential copyright Infringement lawsuits against students (Degrade. 2007. ) The Issue here Is though, the letters are Just half the solution. What happens to the finances of the artist. Times have changed and unlike back in the time of a young Michael Jackson, artists dont make their money in music sales.It used to be- before the threat of PEP networks- that records were being certified 8 and 10 times platinum because of sales. Now a days artists like Maria Carrey, who had a 2005 comeback debut with the Emancipation of Mimi, make the majority of their profits with the sale of tickets for concerts. Maria Carrey who experienced international success with the album went on to get a certification of three times platinum with In Just two months of release. (Billboard. 2007. ) This certification however doesnt take into consideration the number of downloads that were happening before the release up to the date of certification.As the ARIA cracks down on scaring people to get their act together and to purchase songs legally, other orgasm like tunes, the operating program behind the pod and also one of the main (legal) online music providers in the world, has provided an inexpensive way to legally get songs from an internet based program with out all the repercussions of dealing with the ARIA. Although its more common now to use tunes as a music staple, there are people who despite the legality and popularity of the program prefer and advertise the use of the compact disc in its entirety.In An article by Valerie Block of Crannies New York Business, she states thats she wasnt into the free and dangerous downloading websites and programs (Block. 007. ) But as tunes became so popular, she enjoyed the ease of Buying singles for 99 cents and albums for 10 bucks. Like Block, many consumers dont enjoy forking over almost twenty dollars for a disc of material when In fact all they want Is one song. Doug Morris, who Is the head of universal Music Group, wants to- as said by Block- weaken the four-year-old e-tailed;s (tunes) grip on digital music sales. (Block-2007. ) Just as are also people who believe that programs like tunes are taking away the meaning of the entire piece of material by Just downloading single tracks. Personally, as someone who has been downloading music from both tunes and Ares Pro, I fail to see why it would affect the artist in such a manner. To my knowledge, all the artist cares about is the opportunity for their fans to enjoy their material and also to be able to make a profit from it.Block, who is an avid tunes downloaded states that rapper turned business mogul Jay-Z has refused to put his latest work in the tunes store. (Block. 2007. ) The rapper who Just released a theme C. D. Called American Gangster based on the theme of the movie featuring Denned Washington, stated in he article, his album should be purchased in its entirety, like, say, a Picasso. (CTD. In check. ) The issue of downloading programs legality has- in my opinion- been blown Nay out of proportion in many ways.These efforts dont do anything for the artists, as they are depriving the consumers a chance to enjoy the material that the artist have Nortek hard for them to enjoy. Besides, who is the recording industry kidding, no matter the amount of downloads that go on in a day, artists still make money. Between every time a song is played on the radio, played as an advertisement stunt the next Pentane commercial, modeling gigs and appearances and other business endorsements they are making more money than many people.

Tuesday, December 3, 2019

Passing By Nella Larsen Essays - Harlem Renaissance, Passing

Passing By Nella Larsen Nella Larsen's novel, Passing, provides an example of some of the best writing the Harlem Renaissance has to offer. Nella Larsen was one of the most promising young writer's of her time. Though she only published two novels it is clear that she was one of the most important writers of the Harlem Renaissance movement. Her career as writer probably would have lasted longer, but she was accused of plagiarizing her short story, Sanctuary. She was eventually cleared of any wrong doing, but the accusation deeply tarnished her reputation as writer. It is truly a shame that the first African-American woman to win the Guggenheim Fellowship was forced out of writing by scandal. Before being haunted by scandal, Nella Larsen played an intricate role in the Harlem Renaissance. The Harlem Renaissance was a movement that started toward the end of World War I and lasted through the mid 1930's. It was the first notable movement of African-American writers and artists in the United States. It was given the name Harlem Renaissance because the movement was centered in the Harlem district in New York City. More African-American writers and poets were published during this period in the United States than ever before. Not only were African-American writers being published more, but they were also getting a great deal of recognition for their work. The body of work characteristic of this time period showed a heightened sense of racial consciousness. African-American writers during this time were not only seeking to counteract racial prejudice, but were also perpetuating the cultural heritage of Africa. Some of the major writers born from this period include Langston Hughes, Claude McKay, Jean Toomer, Countee Cullen, Neale Hurston and of course, Nella Larsen. The writing of the Harlem Renaissance explored a variety of themes and genres. The writer's experimented with a wide variety of styles as well. Langston Hughes for instance explored the lives of working-class African-Americans. Jean Toomer explored what life was like for very poor African-Americans. Countee Cullen on the other hand explored the problem of racism and the definition of Africa for African-Americans. Nella Larsen explored the restrictions faced by African-Americans according to their skin color. Nella Larsen's novel, Passing was her second as well as last novel and was published in 1929. To get a better idea of what this novel is about, one must understand what exactly passing is. Passing is when African-American men or women with light skin pass themselves off as white in order to enjoy the privileges that were afforded to white people during this period in American history. The Plessy vs. Ferguson ruling of separate, but equal was still in effect at this time in history. Therefore, one could understand why it could be advantageous for African-Americans who had light enough skin to pass themselves off as white. Passing is narrated by the character, Irene Redfield, who is a middle-class, light-skinned African-American woman who deplores passing. She is married to a doctor, with whom she has two sons, who is too dark to pass. Irene is somewhat self-consciously proud of her African heritage. Irene's life is going along as usual when she runs into a childhood friend. Her old friend's name is Clare Kendry. Clare Kendry is a light-skinned African-American woman who passes for white. In fact she is even married to a white doctor. Ironically, Irene runs into her at a rooftop restaurant where she herself is passing to evade the heat wave. The characters in Passing, are faced with the confusion of which race to identify with. They are trapped in limbo between two worlds: white and black. These feelings of being denied privileges if they identify with African-American society and being allowed privileges if they pass as white causes them to feel lonely and feel as though they are not truly part of either race. If they pass they will be allowed to exercise all the privileges that come along with being white during this period of history in America. If they decide to identify themselves as African-American they will be denied many of the most basic privileges given to American citizens. This book explores the trap that light-skinned African-Americans are put in by the Plessy vs. Ferguson ruling of separate, but equal. This ruling is in reality, separate, but not anywhere near equal. Passing proves this to be true. African-Americans would not even entertain the idea of passing if they were not being denied certain rights and privileges. This book is a valuable account of the tragic consequences of being denied racial identity due to a court decision and a society which perpetuates this unfounded prejudice. Is it better to deny